NPro – Histabalance – 60 Capsules

Histabalance is a dietary supplement formulated to provide comprehensive support for managing “functional excess” of histamine in people with reduced histamine-metabolizing capacity, particularly when a DAO (diamine oxidase) deficiency is suspected. The formula combines enzymes (DAO + catalase), plant extracts, and selected nutrients to support both dietary (exogenous) histamine and the mechanisms related to histamine produced within the body (endogenous).

Histamine is produced through the metabolism of amino acids and plays a role in immune, vascular, gastric, and neurological regulation. In cases of histamine intolerance, there is a mismatch between histamine load and the body’s ability to metabolize it.

DAO (from pea sprouts) is the key enzyme in the breakdown of histamine in the intestinal lumen, which is relevant for food-derived histamine.

Catalase provides antioxidant enzymatic support—DAO, when breaking down histamine, can produce hydrogen peroxide (H₂O₂) as a byproduct, which increases oxidative stress. Catalase neutralizes hydrogen peroxide by converting it into water and oxygen, thereby reducing its pro-oxidant effect.

Phytonutritional modulators – quercetin (Sophora japonica), luteolin (Perilla frutescens), tetrahydrocurcuminoids (Curcumin C3 Reduct®), and Nigella sativa are included in the formulation to support pathways associated with histamine production/release and the inflammatory response.

Metabolic and immune cofactors—vitamin C, zinc, copper, manganese, selenium, B6, B9, and B12—are important for antioxidant balance, the immune response, and metabolism.

Elevated histamine levels in the body can cause digestive discomfort, skin reactions, nasal congestion, or headaches, especially after certain meals. Histabalance was designed as a daily supplement for those seeking greater predictability and comfort, combining enzymes that help break down histamine with extracts and nutrients that support the body’s balance.

Its main benefits are:

• Helps break down histamine in food: The combination of DAO and catalase directly supports histamine metabolism, especially during periods when diet or intestinal conditions increase susceptibility.
• Supports food tolerance: By reducing the “effective load” of histamine, it can help manage discomfort associated with meals, especially in people who have identified food triggers.
• Supports digestive comfort: It may be helpful in addressing common complaints related to histamine sensitivity, such as bloating, postprandial discomfort, and a sensation of digestive irritation.
• Support for hypersensitivity reactions: The formula includes compounds such as quercetin and luteolin (among others), which are often used to support the body’s response to irritants.
• Antioxidant defense and immune support: Vitamins and minerals (e.g., vitamin C, zinc, and selenium) contribute to cellular protection and normal immune function, which may be important during periods of increased physiological stress.