No Inflammation of EcogeneticsN is a 100% natural anti-inflammatory, which combines 14 nutrigenomics proven effective to modulate inflammation and pain, providing effective pain relief and no side effects. This unique combination of selected plant components influence signalling kinases and the formation of certain substances, such as PGE2, which are associated with minor pain.

No Inflammation can offer:

- A high degree of cardiovascular, gastric, renal and hepatic safety;
- Effective pain relief without side effects;
- A modulation of the production of Prostaglandins E2 (PGE2) in specific target cells;

It is directed to selective kinase response modulators (SKRMs), to modulate the activity of kinases, for good health. The synergy of oleanolic acid and Rosmarinus officinalis provide high efficacy, with a low dose and an excellent cost-effectiveness, combining uniquely nutrients that support the balance of eicosanoids with natural selective kinase response modulators (SKRMs) that have demonstrated the specific modulation capacity in the tissues of immune system response activities, without interfering with healthy functioning. This formula is designed to work with your body to favorably influence activities associated with less pain, without interfering with the functioning of the healthy inflammatory response. It provides new selective kinase response modulators (SKRMs) that have demonstrated modulating the formation of eicosanoids in target cells without affecting related health promotion activities. This formula is designed for strategic, short-term relief from joint pain. It, too, can be used in the long run without any "ricochet effect". Individual results and recommendations may vary according to the specific needs of the patient. It contains a mixture of natural ingredients, with an excellent safety profile.

Nutritional signals are converted by enzymes known as kinases at the cellular level, helping to command gene expression. Selective Modulators of Response Kinases, or SKRMs, are nutritional substances that can work to bring back to balance kinase signaling, helping to restore healthy signaling to genes, favorably influencing gene expression and reversing the effects of chronic pathologies. When a genetically inadequate diet makes signaling kinases unclear, or even inadequate, SKRMs help increase the volume of the message in view of more positive gene expression and the preservation or restoration of health. These scientific-based nutritional substances offer the newest avenue for a natural approach to well-being, embodied in the ideals of nutrigenomics. 
Some very popular solutions on the market to ensure musculoskeletal integrity or to relieve your associated discomfort can lead to an increased risk of serious adverse effects through prolonged use of certain medications. ECOGENETICS® offers a complete line of formulas, based on science, to promote musculoskeletal health. Including support for healthy bone mineralization and remodeling, as well as support for connective tissue health and to solve problems such as inflammation and pain. Using the knowledge and technologies in the field of nutritional genomics and micronutrition, ECOGENETICS® has designed and developed an efficient combination of nutrients to promote natural inflammation without any side effects. The Formula Without Inflammation can be used alone or in combination with other therapeutic approaches for the treatment of inflammatory processes.

Examples of nutrients that this formula presents: 

Bromelain and Papain - these are proteolytic enzymes that function as SKRMs (Selective Modulators of Kinases of Response) that have been shown to have the ability to modulate specific cell signaling pathways and which can play a role in both acute and chronic inflammation. (Inhibition of NF-kB - Essential transcription factor in inflammatory response. It is this factor that initiates inflammatory processes).

Quercetin - is an SKRM that promotes the low regulation of the Bcl-2 gene (cell regulator that, among other things, prevents autoimmune action in our cells) and, in addition, makes the positive regulation of the expression of Bax (cell regulator that allows the elenation of cells compromised by inflammation). Thus, Bcl-2 significantly decreases and increases bax expression. 

Long turctuation - promotes the cleansing of Reactive Oxygen Species (ROS) and induces the expression of cytoprotective proteins dependent on Nrf2 (a factor that promotes the release of a variety of antioxidant enzymes and detoxifying proteins). Excellence of anti-inflammatory properties, antioxidants and induction of phase 2 enzymes such as hemeoxygenase (HO-1) do. Curcumin produces curcuminoides, curcumin demethoxy (CMD) and curcumin bisdemethoxy (BDMC). CMD has been shown to induce HO-1 (heme oxygenase - anti-inflammatory effect) more effectively than any other substance.  Ginger - has hepato-protective effect, inhibitor of the formation of inflammatory compounds and has direct anti-inflammatory effect by inhibition of inflammatory signaling pathways (chemoquine expression) and accumulate studies that demonstrate its effectiveness in arthritic pain. 

Phosphatidylcholine - is an essential phospholipid for the synthesis and maintenance of healthy cell membranes and free of inflammation.

Boswellia serrata- preparations with the plant Boswellia have been used in traditional Indian medicine for hundreds of years for joint health. The active ingredients are extracted from the gum resin of the Indian incense plant. Scientific studies have shown that it also supports lung and liver health. From the point of view of nutrigenomics, its usefulness derives from its ability, as SKRM, to help support the body's normal inflammatory response by activating genetic transcription factors regulating inflammatory processes. Research also shows its efficacy in inhibiting the lipoxygenase pathway, which is a valuable tool in promoting joint health.

Ashwagandha - is a plant commonly used by Ayurvedic medicine that, nutritionally, has shown that one of its compounds, apocinin, inhibits NADPH oxidase (nicotinamide phosphate adenine) (oxidative and pro-inflammatory factor).

White Willow (Salix alba) - is one of our most classic anti-inflammatory and pain-fighting plants, inhibiting the production of the enzyme cyclooxygenase and sequente decrease of prostaglandins PGE2, formed from aaquidonic acid.

Rosemary (Rosmarinus officinalis) and Olive leaf - prevent kinases from signaling the formation of certain substances, such as PGE2, which are associated with inflammation and pain. (Instill NF-kB - transcription factor, essential in inflammatory response).

Passiflora - very rich in flavonoids, phenols and essential oils of demonstrated sedative and decontracting effects (myorelaxant).

Berberine - Berberine, along with vitamins D3 and K2, effectively support bone renewal as we age.

Harpagophyte - activates Selective Modulators of Kinases of Response (SKRMs), in the form of tetrahydro-iso-alpha acids (THIAA), to modulate the activity of kinases for good health. (Inhibition NF-kB - transcription factor, essential in inflammatory response).