EcogeneticsN Metabolism is a scientifically designed nutrigenomics to support healthy metabolism, maintain healthy blood sugar levels, as well as decrease appetite for sweets and fat absorption.
All this through signaling (through Response Kinases) to the main genes involved and likely to determine profound metabolic changes. The genes whose signaling is indispensable, to counteract metabolic syndrome and, consequently, type 2 diabetes and obesity itself, are:

• EXT2 Exostosin 2 - pancreas development;
• WFS1 Wolfram syndrome 1/wolframin - survival signal beta cells;
• CDKN2A/2B -Cyclin-dependent kinase inhibitor 2A/2B Tumor suppressor gene;
• SCL30A8 Solute carrier family 30 [zinc transporter], member 30 - insulin secretion;
• TCF2/HNF1B HNF1 HomoeoboxB- associated with T2D and (invers) prostata cancer;
• CDKAL1 Cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1:OR 1.39 per allele (p = 0.0004) - Mechanism: Reduced insulin incretion;
• HHEX Homoeobox, haematopoietically expressed: OR 0.81 per allele (p = 0.009) - Mechanism: Reduced insulin incretion;
• IGF2BP2 Insulin-like growth Insulin factor 2 binding protein 2: OR 1.15 per allele (p = 0.049) - Mechanism: pancreas development?, reduced insulin secretion;
• PPARG peroxisome proliferator-activated receptor OR 0.76 per Allel (p = 0.010) - Mechanism: fat regulation;
• FTO Fat mass and obesity associated OR 1.15 per allele (p = 0.047) - Mechanism: Appetite regulation?;
• DGKB isotype of catalytic domain of DAG-kinase - pancreas: DAG/PKC-dependent insulin secretion;
• ADCY5 adenylate cyclase 5 - cAMP-dependent insulin secretion from beta cells; MADD mitogen-activated protein kinase activating death domains - control of ß-cell mass;
• SCL39A13 Solute carrier family 30 [zinc transporter], member 30) - TGF-ß signaling;
• ADRA2A?2A adrenergic receptor - in ß-cell outward potassium channel modifying insulin release;
• FADS1 Fatty acid desaturase - synthesis of PUFA;
• CRY2 cryptochrome 2 - circadian pacemaker; SLACA2 GLUT2-transporter - glucose mediates uptake into ß-cells, liver and other cells;
• IGF1 insulin-like growth factor 1.

The Metabolism formula combines 14 nutrigenomics deeply studied by science and highly effective to give healthcare professionals a precious tool to, in conjunction with a genetically appropriate diet and regular exercise, to maintain, promote or reset:

- Healthy blood sugar levels;
- Normal secretion and sensitivity to insulin;
- A normal secretion and sensitivity to leptin (appetite suppressant hormone);
- A healthy regulation of ghrelin (hormone responsible for feeling hungry);
- A healthy metabolism of carbohydrates, fats (REGULATING THE METABOLISM OF CUMBS) and proteins. 

Examples of nutrients present in this formula:

Gymnema silvestre leaf 25% ac. Gymmemic (Wild Gymnema) - is a plant of Ayurvedic medicine that can help in the normal regeneration and repair of healthy pancreatic beta cells. Research points to its importance in maintaining normal glucose absorption at the intestinal level. Human and animal studies indicate that it can be very useful in supporting a healthy glucose metabolism.

Garcinia cambogia Fruit Dry Extract 60% Hydroxycitric Acid (Garcinia cambogia L.) - This natural extract comes from a tropical fruit grown in various areas of the Asian rainforest. Research has shown that hydroxycitric acid helps maintain a healthy balance of liver lipogenesis and gluconeogenesis, thus preventing excessive conversion of glucose from the carbohydrate-rich diet into body fat. Research also indicates that hydroxycitric acid plays an important role in regulating normal appetite. Unlike many other ingredients hydroxycitric acid is not a central nervous system stimulant.

Bitter Melon 10% charantina (momordica Charantia) - A plant that in recent years has received immense attention for its anti-diabetic properties is the bitter melon, Momordica charantia (M. charantia). Its fruit is also used for the treatment of diabetes and related conditions among indigenous populations in Asia, South America, India and East Africa. Preclinical studies have documented abundant antidiabetic and hypoglycemic effects of M. charantia through various mechanisms.
 

Coleus shoot dry extract with 10% forskolin (Coleus Forskohlii) - increases levels of Cyclic Monophosphate of Adenosine (cAMP), which is involved in metabolic and hormonal processes. Human studies on Coleus have shown to increase lean body mass and support weight management in combination with regular exercise. African Mango 10:1 (Mangifera Indica - Irvingia) - recent studies have shown that individuals who have been given to take African Mango have shown "significant improvements" in their body weight, body fat and abdominal perimeter, as well as a number of parameters that indicate improving heart health, total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels , without changing your diet or exercise routine. Other studies have shown similar results, with subjects losing weight without making other lifestyle changes. And the good news is that, so far, no adverse side effects have been found.

Cinnamon of China (Cinnamomun Cassia) - several studies carried out in recent years point to cinnamon contributing very effectively to maintaining blood glucose levels, while also helping to control appetite and promoting fat burning instead of storage.

Chromium picolinate - in this most bioavailable form, this mineral is essential to promote the effective metabolism of carbohydrates, proteins and fats and regulate the sensitivity of cells to insulin, preventing them from creating resistance to it.

Iodine - Iodine is a structural component of thyroxine and tri-iodothyronine hormones. These hormones control metabolism throughout the body. Proper functioning of thyroid metabolism depends on optimal dietary levels of iode.

 

Alpha lipoic acid - oxidation is a very serious problem in metabolic syndrome and obesity and alpha lipoic acid is unique among biological anti-oxidants because it is soluble in water and lipids. This allows it to neutralize free radicals virtually anywhere in the body, inside and outside cells. Due to its unique sulfur structure, alpha lipoic acid can eliminate various types of free radicals, such as hydroxyl, highly reactive and oxygen-free radicals. Because alpha lipoic acid is involved in so many different antioxidant functions in virtually every tissue in the body, it has been called the universal antioxidant. In addition to being a universal free radical pickup, alpha lipoic acid can also recharge antioxidant systems throughout the body. It can also enhance the activity of vitamins C and E. Alpha lipoic acid can also regenerate glutathione.

L-Carnitine-L-Tartrate - It is an amine that has a fundamental function in the generation of energy by the cell, facilitating the oxidation of free fatty acids and the generation of Adenosine Triphosphate (ATP), synthesized by the body (liver, kidneys and brain) under normal conditions from two essential amino acids, lysine and methionine, requiring for its synthesis the presence of iron, ascorbic acid , niacin and vitamin B6. It is thus responsible for maintaining energy metabolism in all cells of the body, transporting fatty acids through cell membranes to mitochondria, where beta-oxidation (burning) occurs to be transformed into energy. Recent studies attribute to it, among others, the ability to increase physical resistance (energy), balance the immune system, stimulate hair growth by increasing the energy supply to the capillary matrix in the anagen, highly proliferating and energy-consuming phase, and also being a precious aid in the fight against obesity and in the regulation of cholesterol and triglycerides.

L-Taurine - Taurine is one of the most abundant free amino acids in the body. It is crucial in metabolism and is present at particularly high levels in the brain, skeletal muscle, heart and retina of the eye.

Thistle Mariano Seeds Dry Extract 80% Silymarin (Silybum marianum L) - very common plant in the Mediterranean, has been widely used in nutritional support of the liver for over 2000 years. Dried milk thistle flower seeds are rich in silymarin, a flavonolignane complex: silibin, silidianine, silicristina. Silymarin is responsible for the powerful activity of liver protection and regeneration. The liver is the main detoxifying organ of the body, and it is responsible for deactivating toxins such as ethanol, environmental poisons, pesticides and certain pharmaceuticals. In addition to its detoxifying function, the liver plays an essential role in the metabolism of proteins, carbohydrates and lipids, cholesterol synthesis, biliary secretion and storage of fat-soluble vitamins. When damaged or sick, the liver's ability to eliminate toxins and perform its numerous other functions can be severely impaired. Silymarin has been shown to support and improve normal, healthy liver function through three primary actions. By connecting to the outer membrane of the cell, silymarin prevents harmful toxins from entering the cell. Silymarin protects the liver as an important component of the liver's antioxidant defense. But the liver generates toxic free radicals and reactive oxygen species (e.g. peroxides) as a result of its normal metabolism and detoxification functions. In addition, silymarin increases levels of glutathione and superoxide dismutase, two primary antioxidants in the liver. It further stimulates damaged liver cells to regenerate.

Green Tea Dry Leaf Extract 95% Polyphenols, 40% EGCG, 3.5% Caffeine (Camelia sinensis) - It has been shown that green tea helps reduce obesity when consumed daily. The anti-obesity effect of green tea has been associated with its caffeine content and catechins particularly epigallocatechin-3-gallate (EGCG). A number of studies have explored the effects of green tea on overweight and obesity conditions. Many human epidemiological studies have demonstrated the beneficial effects of green tea and its catechins on overweight management. Green tea has been shown to help significantly reduce body mass index (BMI), body weight and body fat, increasing postprandial thermogenesis and fat oxidation. In addition, it has also been shown to reduce blood cholesterol, triglycerides, glucose and insulin levels.

Wild yam root Dry Extract 16% diosgenin ratio 20:1 (Dioscorea opposita) - wild yam is a plant that contains a chemical substance, diosgenin, which can be converted into dehydroepiandrosterone (DHEA). DHEA helps reduce abdominal fat and improve insulin resistance. Other studies suggest that DHEA helps reduce inflammation in the arteries. Many studies point to the benefits of DHEA to treat overweight people, helping to reduce weight and total body fat and LDL cholesterol.